Supporting evidence to change regulations regarding the storage of cryosupernatant plasma

What is this research about?

Canadian Blood Services is a not-for-profit organization whose mission is to manage the supply of blood and blood products in Canada, except for the Province of Québec. The majority of Canadian Blood Services activities involve collecting, producing, testing, and distributing transfusable products (red blood cells, plasma, and platelets). One of the products produced is cryosupernatant plasma which is made by removing the cryoprecipitate from slowly thawed frozen plasma. Most patients receiving cryosupernatant plasma suffer from thrombocytopenic thrombotic purpura (TTP), a disease in which ADAMTS13 (a plasma protein) fails to trim von Willebrand Factor (VWF, another plasma protein) to a size appropriate for healthy function.

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