Research Unit: Modelling risk to ensure safety when considering changes to blood testing

Thursday, February 28, 2019 Dr. Geraldine Walsh

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At Canadian Blood Services, blood safety is paramount. Screening donors for infectious diseases is an important part of our multi-layered approach to blood safety. One such infectious agent that is known to be transmitted through blood transfusion is Human T-cell lymphotropic viruses (or HTLV). Since 1990, all blood donations in Canada have been tested for HTLV, and since then, there have been no identified cases of HTLV transmission by transfusion. The rate of HTLV in Canadian blood donors has not changed in over 20 years of monitoring, and most donations that test positive for HTLV are from first-time donors.

Changes to our blood product manufacturing processes since the 1990s means there may be limited benefit to continuing to test all donations for HTLV. This month’s Research Unit describes a collaborative effort by researchers from the Canadian Blood Services Centre for Innovation and Héma Québec. The researchers wished to understand how the risk of transfusion-transmission of HTLV would change if the screening were modified from the current approach, in which all donations are tested for HTLV, to an alternative approach in which only first-time donors are tested for HTLV. To do this, they used a simulation/modelling study. This modeling study suggests that moving from testing all donations for the virus HTLV, to testing only first-time donors, would have a negligible impact on risk to recipients.

To learn more, read our Research unit here.

Research Units provide clear summaries of the results and impacts of research conducted at Canadian Blood Services. Written by Canadian Blood Services researchers in collaboration with the knowledge mobilization team, these summaries help disseminate research findings to facilitate informed decision-making.

Canadian Blood Services – Driving world-class innovation

Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact

The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency.


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